The Section for Biomedical Image Analysis (SBIA) is devoted to the development of computer-based image analysis methods, and their application to a wide variety of clinical research studies. Image analysis methodologies include image registration, segmentation, population-based statistical analysis, biophysical modeling of anatomical deformations, and high-dimensional pattern classification. Clinical research studies span a variety of clinical areas and organs, and are performed within a wide network of collaborations from within and outside Penn. They include brain diseases such as Alzheimer's and schizophrenia, evaluation of treatment effects in large clinical trials, diagnosis of cardiac diseases, and diagnosis prostate, breast and brain cancer. SBIA also performs small animal imaging research aiming to understand brain development in mouse models.